Abandoned aide, lost and cut off from society (8)
I believe the answer is:
isolated
'cut off from society' is the definition.
'abandoned aide lost' is the wordplay.
'abandoned' indicates an anagram.
'aide'+'lost'='aidelost'
'aidelost' with letters rearranged gives 'ISOLATED'.
'and' is the link.
(Other definitions for isolated that I've seen before include "Without accompaniment" , "Single" , "Placed alone" , "Cut off or left behind" , "Cut off, remote" .)