Accumulate a large amount (5)
I believe the answer is:
amass
'accumulate' is the definition.
(synonyms)
'a large amount' is the wordplay.
'large amount' becomes 'mass' (I've seen this in another clue).
'a'+'mass'='AMASS'
(Other definitions for amass that I've seen before include "Stockpile" , "Assemble" , "Accumulate, heap up" , "Stock up on" , "Be a compiler" .)