Adjustment of liaison to separation (9)
I believe the answer is:
'separation' is the definition.
(I know that isolation is a type of separation)
'adjustment of liaison to' is the wordplay.
'adjustment of' is an anagram indicator (I've seen this in other clues).
'liaisonto' is an anagram of 'ISOLATION'.
(Other definitions for isolation that I've seen before include "keeping apart" , "Quarantine; solitude" , "loneliness" , "Man could display this" , "Separation, solitariness" .)