African-American mostly pursuing knowledge (6)
I believe the answer is:
kenyan
'african' is the definition.
(Kenyan is an example)
'american mostly pursuing knowledge' is the wordplay.
'american mostly' becomes 'yan' (I can't justify this - if you can you should give a lot more credence to this answer).
'pursuing' is a charade indicator (letters next to each other).
'knowledge' becomes 'ken' (ken is a kind of knowledge).
'yan' after 'ken' is 'KENYAN'.
Can you help me to learn more?
(Other definitions for kenyan that I've seen before include "From Mombasa, for example" , "Person from Nairobi, say" , "East African" , "from East Africa?" , "Nationality of native of Nairobi" .)