After comeback concert, man takes fashionable drug (8)
I believe the answer is:
morphine
'after comeback concert' is the definition.
Although both the answer and definition are singular nouns, I cannot understand how they can define each other.
'man takes fashionable drug' is the wordplay.
'man takes' becomes 'morph' (I can't justify this - if you can you should give a lot more credence to this answer).
'fashionable' becomes 'in' (in can mean fashionable or trendy).
'drug' becomes 'e' (E is another name for ecstasy).
'morph'+'in'+'e'='MORPHINE'
Can you help me to learn more?
(Other definitions for morphine that I've seen before include "Nip Homer in the bud and you'll get a powerful painkiller" , "Sedative derived from opium" , "Powerful pain-reliever" , "Opiate for pain relief" , "Pain-killing drug" .)