Again getting up, artist falls (7)
I believe the answer is:
niagara
'falls' is the definition.
(Niagara Falls)
'again getting up artist' is the wordplay.
'getting up' shows that the letters should be reversed in order.
'artist' becomes 'RA' (Royal Academician, member of Royal Academy of Arts).
'again' back-to-front is 'niaga'.
'niaga'+'ra'='NIAGARA'
(Other definitions for niagara that I've seen before include "Great waterfalls on Canadian-US border" , "Great waterfalls on border of USA and Canada" , "North American waterfall" , "N American river and Falls" , "Famous 12" .)