Crossword Genius

Agreement number 500 (3)

Ross

I believe the answer is:

nod

'agreement' is the definition.
(a nod indicates agreement)

'number 500' is the wordplay.
'number' becomes 'no' (abbreviation for 'number').
'500' becomes 'D' (Roman numeral for 500).
'no'+'d'='NOD'

(Other definitions for nod that I've seen before include "Acknowledge by gesture" , "overlook something" , "Drowse" , "Cain was banished to the land of ..." , "Gesture of agreement" .)

I've seen this clue in the Evening Standard.
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