An American woman overseas (6)
I believe the answer is:
abroad
'overseas' is the definition.
(synonyms)
'an american woman' is the wordplay.
'an' becomes 'a'.
'american woman' becomes 'broad'.
'a'+'broad'='ABROAD'
(Other definitions for abroad that I've seen before include "to France, maybe" , "Pole would be so" , "out of UK?" , "In foreign land" , "in Paris, perhaps" .)