An issue for the HSE? One is better off without it! (8)
I believe the answer is:
sickness
'it' is the definition.
The definition suggests a singular noun which matches the answer.
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for sickness that I've seen before include "State of being ill" , "It's not looking good" , "Ailment" , "Illness, disease" , "State of ill-health, malady" .)