Spots cane construction (4)
I believe the answer is:
acne
'spots' is the definition.
(skin condition causing spots)
'cane construction' is the wordplay.
'construction' indicates an anagram (answer constructed from certain letters).
'cane' with letters rearranged gives 'ACNE'.
(Other definitions for acne that I've seen before include "Skin affliction" , "Problem to face in" , "Adolescent skin disease" , "Teenage spots" , "Skin complaint" .)