... and Rene may have to go through a medical procedure (5)
I believe the answer is:
enema
'a medical procedure' is the definition.
(I've seen this before)
'and rene may have' is the wordplay.
'have' says the answer is hidden in the clue.
'ENEMA' can be found hidden inside 'and rene may'.
'to go through' acts as a link.
This may not be correct. Some or all of it may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for enema that I've seen before include "medicine to get you going" , "process to ensure evacuation" , "treatment by rear entrance" , "Colonic irrigation" , "Rectal medicine" .)