Angry speech, losing one deal (5)
I believe the answer is:
trade
'deal' is the definition.
('trade' can be a synonym of 'deal')
'angry speech losing one' is the wordplay.
'angry speech' becomes 'tirade' (I've seen this before).
'losing' suggests deleting specific letters.
'one' becomes 'i' (Roman numeral).
'tirade' with 'i' taken away is 'TRADE'.
(Other definitions for trade that I've seen before include "Skilled occupation" , "Calling" , "Rated (anag.)" , "Buying and selling of goods" , "Buy and sell in business" .)