Annoys canines (6)
I believe the answer is:
hounds
I believe this is a double definition.
'annoys' is the first definition.
(hound can mean to annoy or harass)
'canines' is the second definition.
(hound is a kind of canine)
(Other definitions for hounds that I've seen before include "'You can't run with the hare and hunt with the . . . . . .'" , "Persecutes with dogs?" , "Dogs used for hunting" , "Hunting dogs kept in packs" , "Harasses like hunting dogs" .)