At home aggressive dog may make one suffer (5)
I believe the answer is:
incur
'suffer' is the definition.
(I've seen this before)
'at home aggressive dog' is the wordplay.
'at home' becomes 'in' ('in' can be similar in meaning to 'at home').
'aggressive dog' becomes 'cur' (I've seen this before).
'in'+'cur'='INCUR'
'may make one' acts as a link.
(Other definitions for incur that I've seen before include "Run up" , "Invite, bring about" , "Assume" , "Enter into" , "Bring on as a consequence" .)