At home, nurse is mean (6)
I believe the answer is:
intend
'is mean' is the definition.
(to intend to something is to mean it)
'at home nurse' is the wordplay.
'at' says to put letters next to each other.
'home' becomes 'in' ('he's home' can mean 'he's in').
'nurse' becomes 'tend' (tend can mean to nurse or look after).
'in'+'tend' is 'INTEND'.
(Other definitions for intend that I've seen before include "Mean; propose" , "1 dn [DESIGN]" , "Have as purpose or plan" , "Have as purpose or resolve" , "Mean - purpose" .)