Avoid commercial hosted by the First Lady (5)
I believe the answer is:
evade
'avoid' is the definition.
(evading is a kind of avoiding)
'commercial hosted by the first lady' is the wordplay.
'commercial' becomes 'ad'.
'hosted by' indicates putting letters inside.
'the first lady' becomes 'eve' (I've seen this before**).
'ad' inserted inside 'eve' is 'EVADE'.
(Other definitions for evade that I've seen before include "Fail to pay" , "Shun, escape" , "bypass" , "skirt" , "Dodge - prevaricate" .)