Best, strange as it seems (5)
I believe the answer is:
worst
'best' is the definition.
(I've seen this before)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for worst that I've seen before include "Strangely, best" , "Least well" , "Best; least good" , "Most severe" , "Get better of; very bad" .)