Big game shot (4)
I believe the answer is:
mega
'big' is the definition.
(I've seen this before)
'game shot' is the wordplay.
'shot' indicates an anagram.
'game' is an anagram of 'MEGA'.
(Other definitions for mega that I've seen before include "Great American" , "Smashing" , "ace" , "Informally great or large" , "Game (anag) -- great" .)