Blonde heading to bingo is drunk (6)
I believe the answer is:
blotto
'is drunk' is the definition.
(thesaurus)
'blonde heading to bingo' is the wordplay.
'heading to' suggests taking the first letters.
'bingo' becomes 'lotto' ('lotto' can be a synonym of 'bingo').
The initial letter of 'blonde' is 'b'.
'b'+'lotto'='BLOTTO'
(Other definitions for blotto that I've seen before include "Get very drunk" , "Three sheets to the wind" , "Tight" , "To bolt away slangily drunk" , "Smashed" .)