Bound to upset, surely (2,5)
I believe the answer is:
no doubt
'surely' is the definition.
(I've seen this before)
'bound to upset' is the wordplay.
'upset' is an anagram indicator.
'bound'+'to'='boundto'
'boundto' anagrammed gives 'NO DOUBT'.
(Other definitions for no doubt that I've seen before include "Almost certainly" , "To be sure" , "sign of agreement" , "Surely" , "Bound to, unquestionably" .)