Boy making a profit out of James Bond's boss (5)
I believe the answer is:
gamin
'boy' is the definition.
(thesaurus)
'a profit out of james bond's boss' is the wordplay.
'a profit' becomes 'gain' ('gain' can be a synonym of 'profit').
'out of' means one lot of letters goes inside another (some letters on the outside of others).
'james bond's boss' becomes 'M' (M is the head of MI6 in the James Bond series).
'gain' going around 'm' is 'GAMIN'.
'making' is the link.
(Other definitions for gamin that I've seen before include "Ragged child" , "Little devil" , "Street kid" , "Waif" , "Street urchin or impudent child" .)