Bug lover with awkward set-to looming (12)
I believe the answer is:
entomologist
'bug lover' is the definition.
'awkward set-to looming' is the wordplay.
'awkward' is an anagram indicator.
'set'+'to'+'looming'='settolooming'
'settolooming' with letters rearranged gives 'ENTOMOLOGIST'.
'with' is the link.
(Other definitions for entomologist that I've seen before include "One that finds 24 [INSECT]s" , "Person studying insects" , "Insect scientist" , "Bug expert" , "One who studies insects" .)