Burdened youth went inside (5)
I believe the answer is:
laden
'burdened' is the definition.
(synonyms)
'youth went inside' is the wordplay.
'youth' becomes 'lad' (lad means a young man).
'inside' says to take the centre.
The centre of 'went' is 'en'.
'lad'+'en'='LADEN'
(Other definitions for laden that I've seen before include "Eland (anag)" , "bearing burden" , "Filled (with)" , "Put on board" , "charged a lot" .)