Cacophony from dance club next to the highway (7)
I believe the answer is:
discord
'cacophony' is the definition.
(thesaurus)
'dance club next to the highway' is the wordplay.
'dance club' becomes 'disco' (I've seen this before).
'next to' means one lot of letters go next to another.
'the highway' becomes 'rd'.
'disco'+'rd'='DISCORD'
'from' acts as a link.
(Other definitions for discord that I've seen before include "Dissension" , "cacophony" , "contention" , "Lack of agreement" , "Friction" .)