Came down with Edward for a change of air (6)
I believe the answer is:
rained
'came down' is the definition.
(raining is a kind of coming down)
'edward for a change of air' is the wordplay.
'edward' becomes 'ned' ().
'for' says to put letters next to each other (I've seen this in other clues).
'a change of' indicates an anagram.
'air' is an anagram of 'rai'.
'ned' put after 'rai' is 'RAINED'.
'with' is the link.
(Other definitions for rained that I've seen before include "Precipitated moisture from sky" , "Poured" , "showered" .)