Centrepiece of running buffet sure is tender (5)
I believe the answer is:
nurse
'is tender' is the definition.
(someone who tends to patients)
'centrepiece of running buffet sure' is the wordplay.
'centrepiece of running' becomes 'n' (I can't justify this - if you can you should believe this answer much more).
'buffet' indicates anagramming the letters (I've seen 'buffeted' mean this).
'sure' with letters rearranged gives 'urse'.
'n'+'urse'='NURSE'
Can you help me to learn more?
(Other definitions for nurse that I've seen before include "Entangle" , "One tending the sick" , "Tend the sick" , "drink slowly" , "Look after the sick" .)