Nevertheless, it makes sense, to a man (6)
I believe the answer is:
withal
'nevertheless' is the definition.
('withal' can be a synonym of 'nevertheless')
'sense to a man' is the wordplay.
'sense' becomes 'wit' (I have seen 'Good sense' mean 'wit' so perhaps 'sense' could also mean 'wit').
'to a man' becomes 'hal' (I've seen this before**).
'wit'+'hal'='WITHAL'
'it makes' acts as a link.
This may not be right. Some or all of it may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for withal that I've seen before include "Despite that, notwithstanding" , "it's all the same to Shakespeare" , "nevertheless" , "To boot" , "moreover" .)