Charmer in Soho with time out (8)
I believe the answer is:
smoothie
'charmer' is the definition.
(synonyms)
'soho with time out' is the wordplay.
'with' is a charade indicator (letters next to each other).
'out' indicates anagramming the letters (out can mean wrong or inaccurate).
'soho' after 'time' is 'timesoho'.
'timesoho' with letters rearranged gives 'SMOOTHIE'.
'in' acts as a link.
(Other definitions for smoothie that I've seen before include "Drink made with pureed fruit" , "Sweet talker" , "Plausible person" , "Thick fruity drink - charmer" , "Glib speaker" .)