Children with singular problems (6)
I believe the answer is:
issues
'problems' is the definition.
(I've seen this before)
'children with singular' is the wordplay.
'children' becomes 'issue' (issue can mean someone's offspring).
'with' is a charade indicator (letters next to each other).
'singular' becomes 's' (abbreviation in grammar).
'issue'+'s'='ISSUES'
(Other definitions for issues that I've seen before include "Matters for discussion" , "Controversial subjects" , "Comes forth" , "Egresses" , "Personal problems" .)