City centre has changed under Mayor's lead (10)
I believe the answer is:
manchester
'city' is the definition.
(Manchester is an example)
'centre has changed under mayor's lead' is the wordplay.
'changed' is an anagram indicator.
'under' means one lot of letters go next to another.
'lead' suggests taking the first letters.
The first letter of 'mayors' is 'm'.
'centre'+'has'='centrehas'
'centrehas' with letters rearranged gives 'anchester'.
'anchester' after 'm' is 'MANCHESTER'.
(Other definitions for manchester that I've seen before include "Endurance - it's them (anag)(10.6)" , "City of the Halle Orch." , "English city" , "Synthetic cream (anag)" , "Airport in north-west England" .)