Clean house no more (6)
I believe the answer is:
hoover
'clean' is the definition.
(hoovering is a kind of cleaning)
'house no more' is the wordplay.
'house' becomes 'ho' (abbreviation for house).
'no more' becomes 'over' (I've seen this before).
'ho'+'over'='HOOVER'
(Other definitions for hoover that I've seen before include "J Edgar . . . . . . was FBI chief" , "US president, 1929-33" , "Vacuum-cleaner" , "Former president of US and vacuum cleaner" , "Clean with vacuum cleaner" .)