Collision of new cars preceding hospital (5)
I believe the answer is:
crash
'collision' is the definition.
(synonyms)
'new cars preceding hospital' is the wordplay.
'new' indicates an anagram.
'preceding' means one lot of letters go next to another.
'hospital' becomes 'H' (abbreviation for hospital on maps).
'cars' anagrammed gives 'cras'.
'cras'+'h'='CRASH'
'of' acts as a link.
(Other definitions for crash that I've seen before include "(Of shares) fall suddenly by a great amount" , "Collide violently" , "Economic collapse" , "Violent collision" , "Dramatic fall" .)