Colour of most interest (4)
I believe the answer is:
tint
'colour' is the definition.
(tint is a kind of colour)
'of most interest' is the wordplay.
'of' says the answer is hidden in the clue.
'TINT' is hidden within 'most interest'.
(Other definitions for tint that I've seen before include "Hue, shade" , "A slighth shade of colour" , "A slight shade of colour" , "'Shade, tone (4)'" , "(Softer variety of) colour" .)