Come again following setback: perhaps again cross some cattle (8)
I believe the answer is:
hereford
'some cattle' is the definition.
(Hereford is an example)
'come again following setback perhaps again cross' is the wordplay.
'come again' becomes 'eh' (both are used to ask someone to repeat something).
'following setback' says the letters should be written backwards.
'perhaps again cross' becomes 're-ford' (ford can mean to cross a river).
'eh' written backwards gives 'he'.
'he'+'reford'='HEREFORD'
(Other definitions for hereford that I've seen before include "hardy breed" , "Red-bodied beef cattle with white markings" , "Place" , "English cathedral city" , "City on the River Wye - cattle breed" .)