Comfortable feeling sick? No question (4)
I believe the answer is:
easy
'comfortable' is the definition.
(I know that comfortable can be written as easy)
'feeling sick? no question' is the wordplay.
'feeling sick?' becomes 'queasy' (I've seen this before).
'no' suggests deleting specific letters.
'question' becomes 'qu' (abbreviation).
'queasy' with 'qu' taken out is 'EASY'.
(Other definitions for easy that I've seen before include "Straightforward" , "Effortless, uncomplicated" , "Requiring little effort" , "Soft" , "Presenting few difficulties" .)