Confusion with former prime minister on edge (6)
I believe the answer is:
mayhem
'confusion' is the definition.
(I have seen 'Violent confusion' mean 'mayhem' so perhaps 'confusion' could also mean 'mayhem')
'former prime minister on edge' is the wordplay.
'former prime minister' becomes 'May' (Theresa May former prime minister).
'on' means one lot of letters go next to another.
'edge' becomes 'hem' (I've seen this in another clue).
'may'+'hem'='MAYHEM'
'with' acts as a link.
(Other definitions for mayhem that I've seen before include "Chaos, confusion, destruction" , "Violent damage, chaos" , "State of great confusion and disorder" , "Total havoc" , "Carnage" .)