Criticism from leader about Karachi, initially (4)
I believe the answer is:
flak
'criticism' is the definition.
(I've seen this before)
'from leader about karachi initially' is the wordplay.
'initially' says to take the initial letters.
The initial letters of 'from leader about karachi' is 'FLAK'.
(Other definitions for flak that I've seen before include "stick" , "Shooting" , "heated disagreement" , "Burst of abuse" , "complaints" .)