Cross Italy with speed (5)
I believe the answer is:
irate
'cross' is the definition.
(thesaurus)
'italy with speed' is the wordplay.
'italy' becomes 'i'.
'with' says to put letters next to each other.
'speed' becomes 'rate' (rate is a kind of speed).
'i'+'rate'='IRATE'
(Other definitions for irate that I've seen before include "Annoyed, nettled" , "Aggrieved" , "Angry - furious" , "Wrathful" , "Boiling" .)