Cunning, in the main (4)
I believe the answer is:
deep
This clue is a double definition.
'cunning' is the first definition.
(thesaurus)
'main' is the second definition.
(thesaurus)
'in the' is the link.
(Other definitions for deep that I've seen before include "Heartfelt" , "dangerous for swimming?" , "Intense -- extreme" , "profoundly" , "Bottomless" .)