Cut this out, foremost of paintings in frame (6,2)
I believe the answer is:
stitch up
'frame' is the definition.
(I've seen this before)
'cut this out foremost of paintings' is the wordplay.
'out' indicates anagramming the letters (out can mean wrong or inaccurate).
'foremost of' indicates taking the first letters.
The initial letter of 'paintings' is 'p'.
'cut'+'this'='cutthis'
'cutthis' with letters rearranged gives 'stitchu'.
'stitchu'+'p'='STITCH-UP'
'in' acts as a link.
(Other definitions for stitch up that I've seen before include "Swindle - incriminate - repair" , "Instance of making someone wrongly take the blame" , "Fix (situation) to someone's advantage (colloq.)" , "Unfairly organised situation" , "Swindle; incriminate by informing on" .)