Deal, possibly, with 100 vices (4)
I believe the answer is:
town
'deal possibly' is the definition.
(Deal is a town in Kent)
'with 100 vices' is the wordplay.
'with' becomes 'w' (abbreviation).
'100' becomes 'ton' (I've seen this in other clues).
'vices' means one lot of letters goes inside another.
'w' put inside 'ton' is 'TOWN'.
(Other definitions for town that I've seen before include "Borough" , "Densely populated area" , "more established area with 1a [OLD]" , "What revellers paint red" , "Large urban area" .)