Deal with story about Calvin Klein initially (6)
I believe the answer is:
tackle
'deal with' is the definition.
(I've seen this before)
'story about calvin klein initially' is the wordplay.
'story' becomes 'tale' (synonyms).
'about' means one lot of letters goes inside another.
'initially' suggests taking the first letters.
The initial letters of 'calvin klein' is 'ck'.
'tale' enclosing 'ck' is 'TACKLE'.
(Other definitions for tackle that I've seen before include "block" , "Compete for ball" , "things" , "Go for the person with the ball" , "Take on as in rugby" .)