Dense cad irritated Rose? (8)
I believe the answer is:
ascended
'rose?' is the definition.
('ascend' can be a synonym of 'rise')
'dense cad irritated' is the wordplay.
'irritated' indicates anagramming the letters (letters disturbed or irritated).
'dense'+'cad'='densecad'
'densecad' anagrammed gives 'ASCENDED'.
(Other definitions for ascended that I've seen before include "Climbed, went up" , "R [ROSE]" .)