Irritation (9)
'irritation' is the definition.
(synonyms)
This is all the clue.
(Other definitions for annoyance that I've seen before include "Irritation, vexation" , "trouble" , "Pain" , "Nuisance" , "Source of anger" .)
'irritation' is the definition.
(pique is irritation or annoyance)
This is all the clue.
(Other definitions for pique that I've seen before include "nark" , "Resentful feeling" , "Equip (anag.)" , "A feeling of hurt pride" , "Umbrage; irritation" .)
'irritation' is the definition.
(an itch irritates you)
This is all the clue.
(Other definitions for itch that I've seen before include "Irritating sensation on skin" , "A strong restless desire" , "Hunger, longing" , "Craving" , "Strong desire to do something" .)