Deplore being endlessly cruel (6)
I believe the answer is:
regret
'deplore' is the definition.
(synonyms)
I can't explain the remainder of the clue.
(Other definitions for regret that I've seen before include "Be contrite about" , "Feeling or repentance or sorrow" , "Remorse for something done or left undone" , "Rue - remorse" , "Feel repentance or disappointment" .)