Design from bone set in flexible mica (6)
I believe the answer is:
mosaic
'design' is the definition.
(I have seen 'Tessellated design ' mean 'mosaic' so perhaps 'design' could also mean 'mosaic')
'bone set in flexible mica' is the wordplay.
'bone' becomes 'os' (synonyms).
'set in' indicates putting letters inside.
'flexible' is an anagram indicator (I've seen this in other clues).
'mica' anagrammed gives 'maic'.
'os' inserted into 'maic' is 'MOSAIC'.
'from' acts as a link.
(Other definitions for mosaic that I've seen before include "Pattern made with tiny pieces of stone or glass" , "Design of many small pieces" , "Artistic design of glass or stones" , "Design of small pieces of colored stone or glass (6)." , "Design made of small pieces of colored stone or glass" .)