Difference of opinion sends it awry (7)
I believe the answer is:
dissent
'difference of opinion' is the definition.
(I've seen this in another clue)
'sends it awry' is the wordplay.
'awry' is an anagram indicator.
'sends'+'it'='sendsit'
'sendsit' with letters rearranged gives 'DISSENT'.
(Other definitions for dissent that I've seen before include "Objection" , "Object" , "Open disagreement" , "Express disagreement" , "Differ" .)