Disease overturning male mood (9)
I believe the answer is:
distemper
'disease' is the definition.
(distemper is a kind of disease)
'overturning male mood' is the wordplay.
'overturning' says the letters should be written backwards.
'male' becomes 'Sid' (man's name).
'mood' becomes 'temper' (temper is one's mood or state of mind).
'sid' written backwards gives 'dis'.
'dis'+'temper'='DISTEMPER'
(Other definitions for distemper that I've seen before include "Water-based paint" , "Paint - disease of animals" , "Infectious disease of animals" , "problem for pet" , "Paint for walls; disease" .)