Doctor climbed up and down (6)
I believe the answer is:
morose
'up and down' is the definition.
(I've seen this before)
'doctor climbed' is the wordplay.
'doctor' becomes 'mo' (medical officer).
'climbed' becomes 'rose' (raise and climb can both mean to go up or increase).
'mo'+'rose'='MOROSE'
(Other definitions for morose that I've seen before include "Miserable" , "Rarely" , "Sullen, crabby" , "Moody, glum" , "Sullen or glum." .)