Drink at home to end of bottle, face up on the floor (6)
I believe the answer is:
supine
'face up on the floor' is the definition.
(supine means lying on one's back)
'drink at home to end of bottle' is the wordplay.
'drink' becomes 'sup' (to sup is to drink).
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'to end of' says to take the final letters.
The last letter of 'bottle' is 'e'.
'sup'+'in'+'e'='SUPINE'
(Other definitions for supine that I've seen before include "Slow in acting" , "Lying on one's back - passive" , "Use pin (anag.)" , "Lying face upward" , "looking up" .)